KLHL2 Gene Summary [Human]
Enables actin binding activity and identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KLHL2 |
| Official Name | kelch like family member 2 [Source:HGNC Symbol;Acc:HGNC:6353] |
| Ensembl ID | ENSG00000109466 |
| Bio databases IDs | |
| Aliases | kelch like family member 2, mayven |
| Synonyms | 6030411N21Rik, 8530402H02Rik, ABP-KELCH, kelch-like 2, Mayven, kelch-like family member 2, Klhl2 predicted, LOC100502725, MAV, MAYVEN, RGD1564686 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB_POZ
- protein binding activity, bridging
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
- Galactose oxidase, central domain
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- actin binding
- protein homodimerization
- BTB/POZ domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
- actin stress fibers
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ruffle
- actin cytoskeleton
- cytosol
- Cul3-RING ubiquitin ligase complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding