ARL4C Gene Summary [Human]
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARL4C |
| Official Name | ADP ribosylation factor like GTPase 4C [Source:HGNC Symbol;Acc:HGNC:698] |
| Ensembl ID | ENSG00000188042 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 4C |
| Synonyms | A630084M22Rik, ADP-ribosylation factor-like 4C, ARF like GTPase 4C, Arl4c-ps1, ARL7, LAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL4C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP-ribosylation factor family
- Ras family
- alpha-tubulin binding
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- COVID-19
- colorectal cancer
- lung adenocarcinoma formation
- lung adenocarcinoma
- hypertrophic scarring
- severe acute respiratory syndrome
- Ullrich congenital muscular dystrophy
- pancreatic ductal adenocarcinoma
role in cell
- proliferation
- cell death
- activation in
- migration
- localization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL4C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- filopodium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- alpha-tubulin binding