MARCHF8 Gene Summary [Human]
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | MARCHF8 |
| Official Name | membrane associated ring-CH-type finger 8 [Source:HGNC Symbol;Acc:HGNC:23356] |
| Ensembl ID | ENSG00000165406 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 8 |
| Synonyms | 1300017E09Rik, C-MIR, MARCH8, MARCH-VIII, membrane associated ring-CH-type finger 8, MIR, RNF178 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCHF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class II protein binding
- ermad domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- central domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- prostatic carcinoma
- prostate cancer
- cholelithiasis
- cholecystitis
- gallstone
role in cell
- apoptosis
- number
- expression in
- migration
- proliferation
- Gap 0-Gap 1 phase
- phosphorylation in
- polyubiquitination in
- replication in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- endosomes
- lysosome
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCHF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- protein polyubiquitination
- adaptive immune response
- antigen processing and presentation of peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- late endosome membrane
- endosome
- cytoplasm
- Golgi membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- MHC protein binding