GOSR2 Gene Summary [Human]
This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | GOSR2 |
| Official Name | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] |
| Ensembl ID | ENSG00000108433 |
| Bio databases IDs | |
| Aliases | golgi SNAP receptor complex member 2 |
| Synonyms | 2310032N09Rik, Bos1, EPM6, golgi SNAP receptor complex member 2, GS27, membrin, MYOS, SNARE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOSR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Snare region anchored in the vesicle membrane C-terminus
- protein binding
- SNARE motif
- transporter
Pathways
Biological processes and signaling networks where the GOSR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- atrial flutter
- cardioembolic stroke
- hereditary disorder
- progressive myoclonic epilepsy
- congenital muscular dystrophy with seizures
- heart failure
- idiopathic pulmonary fibrosis
- progressive myoclonic epilepsy type 6
- congenital muscular dystrophy with or without seizures
role in cell
- vesicle transport in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- Golgi-intermediate compartment membrane fractions
- perinuclear Golgi regions
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- peripheral vesicles
- microsomal membrane
- medial Golgi cisternae
- cis Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOSR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- vesicle fusion
- protein transport
- intra-Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- membrane
- ER to Golgi transport vesicle membrane
- cytosol
- SNARE complex
- Golgi membrane
- Golgi apparatus
- nucleoplasm
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding