CRYL1 Gene Summary [Human]
The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CRYL1 |
| Official Name | crystallin lambda 1 [Source:HGNC Symbol;Acc:HGNC:18246] |
| Ensembl ID | ENSG00000165475 |
| Bio databases IDs | |
| Aliases | crystallin lambda 1, crystallin, lamda 1, L-gulonate 3-dehydrogenase, lambda-crystallin homolog |
| Synonyms | 1110025H08Rik, A230106J09Rik, Cry, crystallin lambda 1, crystallin, lambda 1, crystallin λ 1, crystallin, λ 1, GDH, gul3DH, HEL30, lambda-CRY, λ-CRY, λ-Crystallin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRYL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
- NAD or NADH binding
- L-gulonate 3-dehydrogenase
- binding protein
- protein homodimerization
- enzyme
- AdoMet_MTases
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRYL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucuronate catabolic process to xylulose 5-phosphate
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- L-gulonate 3-dehydrogenase activity
- NAD+ binding