Cryl1 Gene Summary [Mouse]
Predicted to enable L-gulonate 3-dehydrogenase activity; NAD+ binding activity; and protein homodimerization activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate. Is active in cytosol. Is expressed in several structures, including alimentary system; hemolymphoid system; metanephros; nose; and secondary oocyte. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cryl1 |
| Official Name | crystallin, lambda 1 [Source:MGI Symbol;Acc:MGI:1915881] |
| Ensembl ID | ENSMUSG00000021947 |
| Bio databases IDs | |
| Aliases | crystallin, lambda 1 |
| Synonyms | 1110025H08Rik, A230106J09Rik, Cry, crystallin lambda 1, crystallin, lambda 1, crystallin λ 1, crystallin, λ 1, GDH, gul3DH, HEL30, lambda-CRY, λ-CRY, λ-Crystallin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cryl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
- NAD or NADH binding
- L-gulonate 3-dehydrogenase
- binding protein
- protein homodimerization
- enzyme
- AdoMet_MTases
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cryl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucuronate catabolic process to xylulose 5-phosphate
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- L-gulonate 3-dehydrogenase activity
- NAD+ binding