PER2 Gene Summary [Human]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | PER2 |
| Official Name | period circadian regulator 2 [Source:HGNC Symbol;Acc:HGNC:8846] |
| Ensembl ID | ENSG00000132326 |
| Bio databases IDs | |
| Aliases | period circadian regulator 2 |
| Synonyms | AC0124852, AC012485.2, FASPS, FASPS1, KIAA0347, LOC105373961, mKIAA0347, mPer2, period circadian clock 2, period circadian regulator 2, rPER2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PER2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Period protein 2/3C-terminal region
- transcription regulator
- ligand-dependent nuclear receptor interactor
- dimerization domain
- transcription co-activator
- nucleic acid binding
- PAS
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- PAS fold
- RNA binding
- kinase binding
- double-stranded DNA binding
- PAS domain
Pathways
Biological processes and signaling networks where the PER2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hemolysis
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- neoplasia
- familial advanced sleep phase syndrome type 1
- hyperplasia
role in cell
- expression in
- cell viability
- apoptosis
- migration
- differentiation
- proliferation
- cell cycle progression
- number
- remodeling
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PER2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of circadian rhythm
- negative regulation of circadian rhythm
- negative regulation of transcription from RNA polymerase II promoter
- white fat cell differentiation
- regulation of insulin secretion
- circadian regulation of gene expression
- chromatin remodeling
- circadian regulation of translation
- response to ischemia
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- entrainment of circadian clock by photoperiod
- negative regulation of fat cell proliferation
- negative regulation of protein ubiquitination
- negative regulation of transcription regulatory region DNA binding
- regulation of cell cycle
- regulation of glutamate uptake involved in transmission of nerve impulse
- lactate biosynthetic process
- regulation of vasoconstriction
- gluconeogenesis
- circadian rhythm
- fatty acid metabolic process
- glycogen biosynthetic process
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding