CLPP Gene Summary [Human]
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLPP |
| Official Name | caseinolytic mitochondrial matrix peptidase proteolytic subunit [Source:HGNC Symbol;Acc:HGNC:2084] |
| Ensembl ID | ENSG00000125656 |
| Bio databases IDs | |
| Aliases | caseinolytic mitochondrial matrix peptidase proteolytic subunit, ATP-dependent protease ClpAP (E. coli), proteolytic subunit, human |
| Synonyms | caseinolytic mitochondrial matrix peptidase proteolytic subunit, D17Wsu160e, DFNB81, PRLTS3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLPP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase
- Clp protease
- crotonase-like
- serine endopeptidase
- peptidase
- endopeptidase Clp
- handle region
- protein binding
- ATP-dependent peptidase
- identical protein binding
Pathways
Biological processes and signaling networks where the CLPP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Perrault syndrome type 1
- Perrault syndrome type 3
- insulin resistance
- impaired glucose tolerance
- obesity
- hepatic steatosis
role in cell
- expression in
- apoptosis
- proliferation
- transmembrane potential
- formation
- size
- fission
- accumulation in
- generation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLPP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein catabolic process
- misfolded or incompletely synthesized protein catabolic process
- membrane protein proteolysis
- proteolysis
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- endopeptidase Clp complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- endopeptidase activity
- serine-type endopeptidase activity
- ATP-dependent peptidase activity
- peptidase activity
- ATPase binding