PCF11 Gene Summary [Human]
The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | PCF11 |
| Official Name | PCF11 cleavage and polyadenylation factor subunit [Source:HGNC Symbol;Acc:HGNC:30097] |
| Ensembl ID | ENSG00000165494 |
| Bio databases IDs | |
| Aliases | PCF11 cleavage and polyadenylation factor subunit |
| Synonyms | 2500001H09Rik, 5730417B17RIK, PCF11 cleavage and polyadenylation factor subunit, RGD1563397 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCF11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal-binding protein interaction domain
- VHS, ENTH and ANTH domain superfamily
- enzyme binding
- CID domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCF11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- termination of RNA polymerase II transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- mRNA cleavage factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- mRNA binding
- RNA polymerase II core binding