RBM14 Gene Summary [Human]
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | RBM14 |
| Official Name | RNA binding motif protein 14 [Source:HGNC Symbol;Acc:HGNC:14219] |
| Ensembl ID | ENSG00000239306 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 14, coactivator activator, SYT interacting protein |
| Synonyms | 1300007E16Rik, CoAA, COACTIVATOR ACTIVATOR, LOC100911677, MGC15912, p16, p16K, PSP2, RNA binding motif protein 14, SIP, Sytip, SYTIP1, TMEM137 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- transcription co-activator
- RNA recognition motif
- mRNA binding
- protein binding
- TRBP interacting domain
- prion-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell cancer
- renal cell carcinoma
role in cell
- expression in
- proliferation
- production in
- accumulation in
- apoptosis
- replication in
- acetylation in
- transactivation in
- G1/S phase transition
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- activation of innate immune response
- innate immune response
- apoptotic process
- negative regulation of centriole replication
- positive regulation of transcription from RNA polymerase II promoter
- response to hormone stimulus
- gastrulation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- nuclear speck
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- mRNA binding