PRDX3 Gene Summary [Human]
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | PRDX3 |
| Official Name | peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354] |
| Ensembl ID | ENSG00000165672 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 3 |
| Synonyms | AOP-1, D0Tohi1, Ef2l, HBC189, MER5, MTAP, peroxiredoxin 3, PPPCD, PRO1748, Prx3, PRX III, SCAR32, SP-22, TDXM, THIOREDUCTASE DEPENDANT PEROXIDE REDUCTASE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRDX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxiredoxin
- protein kinase binding
- Thioredoxin-like
- C-terminal domain of 1-Cys peroxiredoxin
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- caspase inhibitor activity
- thioredoxin peroxidase
- signal peptide
- AhpC/TSA family
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immune thrombocytopenia
- weight gain
- Alzheimer disease
- autosomal recessive spinocerebellar ataxia type 32
- Fanconi anemia group J
- Fanconi anemia group I
- autosomal recessive cerebellar ataxia
- insulin resistance
- punctiform and polychromatic pre-Descemet corneal dystrophy
- Fanconi anemia, group D1
role in cell
- expression in
- transmembrane potential
- proliferation
- apoptosis
- size
- differentiation
- transformation
- function
- hypertrophy
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- microsome
- mitochondrial matrix
- nucleoplasm
- early endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRDX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- cell redox homeostasis
- response to hydrogen peroxide
- positive regulation of NF-kappaB transcription factor activity
- mitochondrion organization
- maternal placenta development
- hydrogen peroxide catabolic process
- response to oxidative stress
- peptidyl-cysteine oxidation
- regulation of mitochondrial membrane potential
- negative regulation of apoptotic process
- myeloid cell differentiation
- cellular response to oxidative stress
- cellular response to stress
- response to lipopolysaccharide
- negative regulation of kinase activity
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- macromolecular complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- thioredoxin peroxidase activity
- alkyl hydroperoxide reductase activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process