STOX1 Gene Summary [Human]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein phosphorylation; and regulation of gene expression. Located in centrosome; cytosol; and nuclear lumen. Implicated in pre-eclampsia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STOX1 |
| Official Name | storkhead box 1 [Source:HGNC Symbol;Acc:HGNC:23508] |
| Ensembl ID | ENSG00000165730 |
| Bio databases IDs | |
| Aliases | storkhead box 1 |
| Synonyms | 4732470K04Rik, C10orf24, Gm63, RGD1310622, storkhead box 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STOX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Winged helix Storkhead-box1 domain
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- preeclampsia
- acute myeloid leukemia
- schizophrenia
- insomnia
- degeneration of lumbar intervertebral disc
- preeclampsia eclampsia 4
role in cell
- expression in
- organization
- cell cycle progression
- abnormal morphology
- response by
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cell cortex
- Nucleus
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STOX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- positive regulation of G1/S transition of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- cell division
- negative regulation of gene expression
- regulation of mitochondrial membrane potential
- positive regulation of gene expression
- regulation of gene expression
- positive regulation of peptidyl-threonine phosphorylation
- regulation of mitochondrion organization
- cellular response to nitrosative stress
- positive regulation of protein kinase B signaling cascade
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cell cortex
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding