DDX21 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DDX21 |
| Official Name | DExD-box helicase 21 [Source:HGNC Symbol;Acc:HGNC:2744] |
| Ensembl ID | ENSG00000165732 |
| Bio databases IDs | |
| Aliases | DExD-box helicase 21, nucleolar RNA helicase 2 |
| Synonyms | D10Ertd645e, D10Wsu42e, Ddx21a, Ddx21b, DExD-box helicase 21, GUA, gu-alpha, GURDB, gu-α, II/Gu, RH, RH-II/GU, RH-II/GuA, RNA HELICASE GUALPHA, SIMILAR TO RBP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- rRNA binding
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme inhibitor activity
- enzyme
- protein binding
- RNA-binding GUCT domain found in the RNA helicase II/Gu protein family
- identical protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- RNA binding
- helicase domain
- double-stranded RNA binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- snoRNA binding
- CRISPR-associated helicase Cas3
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- metastasis
- liver cancer
- keloid disease
- lung cancer
- organismal death
- insomnia
- colon cancer
- glioblastoma
role in cell
- apoptosis
- growth
- cell viability
- expression in
- survival
- phosphorylation in
- colony formation
- migration
- proliferation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- transcription from RNA polymerase II promoter
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase I promoter
- chromatin remodeling
- positive regulation of myeloid dendritic cell cytokine production
- response to exogenous dsRNA
- innate immune response
- osteoblast differentiation
- defense response to virus
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- miRNA binding
- ATP binding
- identical protein binding
- RNA binding
- snoRNA binding
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- mRNA binding
- rRNA binding