RAB10 Gene Summary [Human]
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | RAB10 |
| Official Name | RAB10, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9759] |
| Ensembl ID | ENSG00000084733 |
| Bio databases IDs | |
| Aliases | RAB10, member RAS oncogene family, ras-related GTP-binding protein |
| Synonyms | Ac1075, RAB10, member RAS oncogene family, Similar to rab10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- myosin binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- neoplasia
- sickle cell anemia
- hepatocellular carcinoma
- liver cancer
- acute lung injury
- digestive system disorder
- acute myeloid leukemia
role in cell
- expression in
- formation
- proliferation
- cell viability
- binding
- binding in
- development
- abnormal morphology
- activation
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular nanovesicle
- synaptic vesicle membrane
- cytoplasmic vesicle membrane
- exocytic vesicle
- endoplasmic reticulum tubules
- cilia
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- synaptic vesicles
- recycling endosomes
- early endosomes
- perinuclear vesicles
- GLUT4 vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- presynaptic terminals
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi to plasma membrane transport
- Golgi to plasma membrane protein transport
- establishment of protein localization in endoplasmic reticulum membrane
- exocytosis
- establishment of protein localization in membrane
- protein secretion
- cellular response to insulin stimulus
- vesicle-mediated transport
- polarized epithelial cell differentiation
- establishment of neuroblast polarity
- axonogenesis
- regulated secretory pathway
- endosomal transport
- antigen processing and presentation
- endoplasmic reticulum tubular network organization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- insulin-responsive compartment
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum membrane
- exocytic vesicle
- secretory granule membrane
- trans-Golgi network
- endosome
- extracellular vesicular exosome
- focal adhesion
- cilium
- cytosol
- plasma membrane
- exocyst
- adherens junction
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoskeleton
- endoplasmic reticulum tubular network
- membrane
- phagocytic vesicle membrane
- recycling endosome
- endosome membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- small monomeric GTPase activity
- GDP binding
- myosin V binding