Neto1 Gene Summary [Mouse]
Enables ionotropic glutamate receptor binding activity. Involved in learning or memory; modulation of chemical synaptic transmission; and protein localization to synapse. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located in excitatory synapse and postsynaptic density. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neto1 |
| Official Name | neuropilin (NRP) and tolloid (TLL)-like 1 [Source:MGI Symbol;Acc:MGI:2180216] |
| Ensembl ID | ENSMUSG00000050321 |
| Bio databases IDs | |
| Aliases | neuropilin (NRP) and tolloid (TLL)-like 1 |
| Synonyms | AI851453, BCTL1, BTCL1, C130005O10Rik, neuropilin and tolloid like 1, neuropilin (NRP) and tolloid (TLL)-like 1, RGD1566269 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neto1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- LDLa
- protein binding
- ionotropic glutamate receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- global developmental delay with intellectual disability
- pervasive developmental disorder
- tinnitus
- exostoses
- cleft palate
- cleft lip
- idiopathic scoliosis
- Cornelia de Lange syndrome
role in cell
- desensitization in
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cellular membrane
- synaptic membrane
- synaptosomes
- synapse
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neto1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term neuronal synaptic plasticity
- visual learning
- positive regulation of excitatory postsynaptic membrane potential
- memory
- regulation of kainate selective glutamate receptor activity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- excitatory synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding