PEX11A Gene Summary [Human]
This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Details
| Type | Processed Transcript |
| Official Symbol | PEX11A |
| Official Name | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] |
| Ensembl ID | ENSG00000166821 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 11 alpha, Peroxisomal membrane protein 11A, Peroxin-11A, peroxisomal integral membrane protein 28-kDa |
| Synonyms | 26 Kd pmp, hsPEX11p, Peroxisomal biogenesis factor, peroxisomal biogenesis factor 11 alpha, peroxisomal biogenesis factor 11 α, PEX11-ALPHA, PEX11-α, Pmp26p, PMP28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PEX11A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peroxisomal biogenesis factor 11 (PEX11)
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- squamous cell cancer
- obesity
- tubulo-interstitial fibrosis
- weight gain
- non-insulin-dependent diabetes mellitus
- peroxisome biogenesis disorder
- interstitial nephritis
- squamous-cell carcinoma
role in cell
- proliferation
- activity
- number
- cell death
- biogenesis
- differentiation
- abnormal morphology
- fission
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PEX11A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peroxisome membrane biogenesis
- brown fat cell differentiation
- peroxisome fission
- signal transduction
- regulation of peroxisome size
- peroxisome organization
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity