FIS1 Gene Summary [Human]
Enables identical protein binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular calcium ion homeostasis; and mitochondrion organization. Acts upstream of or within mitochondrion morphogenesis. Located in mitochondrion and peroxisome. Is integral component of mitochondrial outer membrane and integral component of peroxisomal membrane. Part of protein-containing complex. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FIS1 |
| Official Name | fission, mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:21689] |
| Ensembl ID | ENSG00000214253 |
| Bio databases IDs | |
| Aliases | fission, mitochondrial 1, CGI-135 protein, mitochondrial fission molecule |
| Synonyms | 2010003O14Rik, CGI-135, fission, mitochondrial 1, Riken cDNA 2010003o14, TTC11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FIS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- alpha helix
- transmembrane domain
- protein binding
- Mitochondrial Fission Protein Fis1, cytosolic domain
- identical protein binding
- tetratricopeptide repeat
- sorting signal domain
- Fis1 N-terminal tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the FIS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- muscular atrophy
- breast cancer
role in cell
- expression in
- proliferation
- apoptosis
- quantity
- mitochondrial fission
- swelling
- granularity
- response by
- fragmentation
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- mitochondrial outer membrane
- peroxisome membrane
- neurites
- peroxisomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FIS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid transport
- peroxisome fission
- positive regulation of protein targeting to membrane
- mitochondrial fusion
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of mitochondrial fission
- mitochondrion degradation
- mitochondrion organization
- mitochondrial fission
- protein targeting to mitochondrion
- release of cytochrome c from mitochondria
- regulation of mitochondrion organization
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- mitochondrion
- membrane
- cytosol
- macromolecular complex
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding
- binding, bridging