Pex11a Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex11a |
| Official Name | peroxisomal biogenesis factor 11 alpha [Source:MGI Symbol;Acc:MGI:1338788] |
| Ensembl ID | ENSMUSG00000030545 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 11 alpha |
| Synonyms | 26 Kd pmp, hsPEX11p, Peroxisomal biogenesis factor, peroxisomal biogenesis factor 11 alpha, peroxisomal biogenesis factor 11 α, PEX11-ALPHA, PEX11-α, Pmp26p, PMP28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pex11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peroxisomal biogenesis factor 11 (PEX11)
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- squamous cell cancer
- obesity
- tubulo-interstitial fibrosis
- weight gain
- non-insulin-dependent diabetes mellitus
- peroxisome biogenesis disorder
- interstitial nephritis
- squamous-cell carcinoma
role in cell
- proliferation
- activity
- number
- cell death
- biogenesis
- differentiation
- abnormal morphology
- fission
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pex11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peroxisome membrane biogenesis
- brown fat cell differentiation
- peroxisome fission
- signal transduction
- regulation of peroxisome size
- peroxisome organization
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity