LASP1 Gene Summary [Human]
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | LASP1 |
| Official Name | LIM and SH3 protein 1 [Source:HGNC Symbol;Acc:HGNC:6513] |
| Ensembl ID | ENSG00000002834 |
| Bio databases IDs | |
| Aliases | LIM and SH3 protein 1 |
| Synonyms | Def-4, LIM and SH3 protein 1, MLN 50, SH3P6, Tg(Col1a1-lacZ)1Ngma |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LASP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- ion transporter
- protein binding
- zDHHC ankyrin repeat binding domain
- transporter
- Src Homology 3 domain superfamily
- Nebulin repeat
Pathways
Biological processes and signaling networks where the LASP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- diffuse systemic sclerosis
role in cell
- expression in
- proliferation
- adhesion
- formation
- migration
- invasion by
- phosphorylation in
- binding in
- invasion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- cytoskeleton
- postsynaptic region
- focal adhesions
- Nucleus
- cytosol
- cell membrane-lagging edges
- dendritic spines
- growth cone
- actin stress fibers
- pseudopodia
- filopodia
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LASP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- metal ion binding
- cadherin binding
- ion transmembrane transporter activity