IP6K1 Gene Summary [Human]
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | IP6K1 |
| Official Name | inositol hexakisphosphate kinase 1 [Source:HGNC Symbol;Acc:HGNC:18360] |
| Ensembl ID | ENSG00000176095 |
| Bio databases IDs | |
| Aliases | inositol hexakisphosphate kinase 1 |
| Synonyms | 1200016D08Rik, IHPK1, inositol hexakisphosphate kinase 1, inositol hexaphosphate kinase 1, InsP6, InsP6k1, Itpk6, LOC100506738, PiUS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IP6K1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- diphosphoinositol-pentakisphosphate kinase
- phosphate group acceptor phosphotransferase
- inositol-hexakisphosphate kinase
- alcohol group acceptor phosphotransferase
- Inositol polyphosphate kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- insomnia
- azoospermia
- major depression
- growth failure
regulated by
- tetradecanoylphorbol acetate
- Influenza A virus (A/Japan/305/57(H2N2))
- valproic acid
- beta-estradiol
- IP6K1
- lithium
- 18:1 phosphatidic acid
role in cell
- phosphorylation in
- expression in
- cell viability
- cell death
- cell cycle progression
- recovery
- methylation in
- homologous recombination repair in
- localization in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IP6K1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- inositol phosphate metabolic process
- phosphatidylinositol phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol heptakisphosphate kinase activity
- inositol hexakisphosphate kinase activity
- protein binding
- inositol-1,3,4,5,6-pentakisphosphate kinase activity
- inositol diphosphate tetrakisphosphate kinase activity
- inositol 5-diphosphate pentakisphosphate 5-kinase activity
- inositol hexakisphosphate 5-kinase activity
- inositol hexakisphosphate 3-kinase activity
- inositol hexakisphosphate 1-kinase activity