DIS3L Gene Summary [Human]
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | DIS3L |
| Official Name | DIS3 like exosome 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:28698] |
| Ensembl ID | ENSG00000166938 |
| Bio databases IDs | |
| Aliases | DIS3 like exosome 3'-5' exoribonuclease |
| Synonyms | DIS3L1, DIS3-like exosome 3'-5' exoribonuclease, RGD1308959 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DIS3L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- Dis3-like cold-shock domain 2 (CSD2)
- S1 domain
- ribonuclease R
- exoribonuclease II
- RNB domain
- VacB and RNase II family 3'-5' exoribonucleases
- enzyme binding
- enzyme
- protein binding
- PIN (PilT N terminus) domain: Superfamily
- This domain is the catalytic domain of ribonuclease II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DIS3L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA catabolic process
- RNA processing
- mRNA catabolic process
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- centrosome
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- exoribonuclease II activity
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- enzyme binding