EXOSC7 Gene Summary [Human]
Predicted to enable 3'-5'-exoribonuclease activity and RNA binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | EXOSC7 |
| Official Name | exosome component 7 [Source:HGNC Symbol;Acc:HGNC:28112] |
| Ensembl ID | ENSG00000075914 |
| Bio databases IDs | |
| Aliases | exosome component 7 |
| Synonyms | 2610002K22RIK, EAP1, Exosome component 7, hRrp42p, KIAA0116, mKIAA0116, p8, RRP42, Rrp42p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOSC7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3' exoribonuclease family, domain 2
- 3'-5' exoribonuclease
- RNase PH-like 3'-5' exoribonucleases
- enzyme
- protein binding
- 3' exoribonuclease family, domain 1
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXOSC7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- U4 snRNA 3'-end processing
- U1 snRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process
- RNA processing
- rRNA processing
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- RNA catabolic process
- nuclear polyadenylation-dependent rRNA catabolic process
- nuclear mRNA surveillance
- nuclear polyadenylation-dependent tRNA catabolic process
- U5 snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nucleus
- nuclear exosome (RNase complex)
- cytosol
- nucleolus
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- exoribonuclease activity