ATP5MG Gene Summary [Human]
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | ATP5MG |
| Official Name | ATP synthase membrane subunit g [Source:HGNC Symbol;Acc:HGNC:14247] |
| Ensembl ID | ENSG00000167283 |
| Bio databases IDs | |
| Aliases | ATP synthase membrane subunit g |
| Synonyms | 4933437C06RIK, ATP5JG, ATP5L, Atp synthase (f0f1), subunit g, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, ATP synthase membrane subunit G, F1F0-ATP Synthase G Subunit, RGD:1303259 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP5MG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosine-tetraphosphatase
- enzyme
- protein binding
- Mitochondrial ATP synthase g subunit
- hydrogen-transporting ATP synthase activity, rotational mechanism
- H+-exporting ATPase
Pathways
Biological processes and signaling networks where the ATP5MG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- major depression
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- early onset hypertension
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cristae-like membrane
- Mitochondria
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP5MG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism