Atp5l Gene Summary [Mouse]
Predicted to enable P-type proton-exporting transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and genitourinary system. Orthologous to several human genes including ATP5MG (ATP synthase membrane subunit g). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atp5l |
| Official Name | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G [Source:MGI Symbol;Acc:MGI:1351597] |
| Ensembl ID | ENSMUSG00000038717 |
| Bio databases IDs | |
| Aliases | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G |
| Synonyms | 4933437C06RIK, ATP5JG, ATP5L, Atp synthase (f0f1), subunit g, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, ATP synthase membrane subunit G, F1F0-ATP Synthase G Subunit, RGD:1303259 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp5l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosine-tetraphosphatase
- enzyme
- protein binding
- Mitochondrial ATP synthase g subunit
- hydrogen-transporting ATP synthase activity, rotational mechanism
- H+-exporting ATPase
Pathways
Biological processes and signaling networks where the Atp5l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- major depression
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- early onset hypertension
regulates
- H+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cristae-like membrane
- Mitochondria
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp5l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism