PSCA Gene Summary [Human]
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Details
| Type | Processed Transcript |
| Official Symbol | PSCA |
| Official Name | prostate stem cell antigen [Source:HGNC Symbol;Acc:HGNC:9500] |
| Ensembl ID | ENSG00000167653 |
| Bio databases IDs | |
| Aliases | prostate stem cell antigen |
| Synonyms | 2210408B04Rik, lncPSCA, PRO232, prostate stem cell antigen |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSCA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- organismal death
- duodenal ulcer
- gastric ulcer
- bladder cancer
- prostate cancer
- breast carcinoma
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
role in cell
- proliferation
- expression in
- cell death
- migration
- cell viability
- growth
- invasion by
- 5-fluorouracil sensitivity
- oxaliplatin sensitivity
- irinotecan sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSCA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor binding