Psca Gene Summary [Mouse]
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor regulator activity. Predicted to be involved in acetylcholine receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; and regulation of neurotransmitter receptor activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system epithelium; genitourinary system; oral cavity; and skin. Orthologous to human PSCA (prostate stem cell antigen). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psca |
| Official Name | prostate stem cell antigen [Source:MGI Symbol;Acc:MGI:1919623] |
| Ensembl ID | ENSMUSG00000022598 |
| Bio databases IDs | |
| Aliases | prostate stem cell antigen |
| Synonyms | 2210408B04Rik, lncPSCA, PRO232, prostate stem cell antigen |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- organismal death
- duodenal ulcer
- gastric ulcer
- bladder cancer
- prostate cancer
- breast carcinoma
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
role in cell
- proliferation
- expression in
- cell death
- migration
- cell viability
- growth
- invasion by
- 5-fluorouracil sensitivity
- oxaliplatin sensitivity
- irinotecan sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor binding