RCOR2 Gene Summary [Human]
Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RCOR2 |
| Official Name | REST corepressor 2 [Source:HGNC Symbol;Acc:HGNC:27455] |
| Ensembl ID | ENSG00000167771 |
| Bio databases IDs | |
| Aliases | REST corepressor 2 |
| Synonyms | 1A13, CoREST, LOC100911770, Rcor, Rcor1, REST corepressor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCOR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- ELM2 domain
- Myb-like DNA-binding domain
- transcription co-repressor
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the RCOR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RCOR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- histone deacetylase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- enzyme binding