CDC73 Gene Summary [Human]
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
Details
| Type | Processed Transcript |
| Official Symbol | CDC73 |
| Official Name | cell division cycle 73 [Source:HGNC Symbol;Acc:HGNC:16783] |
| Ensembl ID | ENSG00000134371 |
| Bio databases IDs | |
| Aliases | cell division cycle 73, Paf1/RNA polymerase II complex component |
| Synonyms | 8430414L16RIK, BC027756, C130030P16Rik, C1orf28, C81219, cell division cycle 73, cell division cycle 73, Paf1/RNA polymerase II complex component, FIHP, HPRT2, HPTJT, HRPT1, HRPT2, HYX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC73 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paf1 complex subunit CDC73 N-terminal
- RNA pol II accessory factor, Cdc73 family, C-terminal
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mixed neoplasia
- renal neoplasia
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- head and neck cancer
- breast cancer
- aortic valve calcification
- hereditary cancer-predisposing syndrome
role in cell
- expression in
- proliferation
- apoptosis
- growth
- phosphorylation in
- replication in
- differentiation
- binding in
- transactivation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC73 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- negative regulation of myeloid cell differentiation
- negative regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- protein destabilization
- positive regulation of transcription elongation from RNA polymerase II promoter
- cellular response to lipopolysaccharide
- endodermal cell fate commitment
- regulation of cell growth
- negative regulation of fibroblast proliferation
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- positive regulation of mRNA 3'-end processing
- Wnt receptor signaling pathway
- mRNA 3'-end processing
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- Cdc73/Paf1 complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core binding