E4F1 Gene Summary [Human]
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | E4F1 |
| Official Name | E4F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3121] |
| Ensembl ID | ENSG00000167967 |
| Bio databases IDs | |
| Aliases | E4F transcription factor 1 |
| Synonyms | Dnase1l2, E4F, E4F transcription factor 1, p120E4F, phi-AP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human E4F1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- E4F DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- C2H2-type zinc finger
- DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- exercise intolerance
- lactic acidemia
- acute myeloid leukemia
role in cell
- expression in
- phosphorylation in
- proliferation
- cell death
- apoptosis
- accumulation in
- activity
- oxidation in
- G2 phase
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spindle apparatus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human E4F1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- regulation of mitotic cell cycle, embryonic
- DNA replication
- regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
- regulation of cell cycle process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- spindle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- cAMP response element binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- transferase activity