ING5 Gene Summary [Human]
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | ING5 |
| Official Name | inhibitor of growth family member 5 [Source:HGNC Symbol;Acc:HGNC:19421] |
| Ensembl ID | ENSG00000168395 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family member 5 |
| Synonyms | 1700001C14Rik, 1700027H23Rik, 1810018M11Rik, AI225768, BAIP1, inhibitor of growth family member 5, inhibitor of growth family, member 5, LOC101927187, p28ING5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ING5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- protein binding activity, bridging
- PHD finger superfamily
- Inhibitor of growth (ING) domain family
- chromatin binding
- protein binding
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- diverticular disease
- carcinoma in situ
- epithelial cancer in situ
- uterine leiomyoma
- leiomyomatosis
role in cell
- growth
- proliferation
- phosphorylation in
- apoptosis
- cell viability
- colony formation
- abnormal morphology
- acetylation in
- cell cycle progression
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ING5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- negative regulation of cell proliferation
- apoptotic signaling pathway
- regulation of transcription, DNA-dependent
- protein acetylation
- regulation of DNA replication
- fibroblast proliferation
- regulation of developmental process
- regulation of cell growth
- negative regulation of fibroblast proliferation
- positive regulation of apoptotic process
- regulation of DNA biosynthetic process
- regulation of cell cycle
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- MOZ/MORF histone acetyltransferase complex
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- methylated histone residue binding
- chromatin binding