CDC40 Gene Summary [Human]
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | CDC40 |
| Official Name | cell division cycle 40 [Source:HGNC Symbol;Acc:HGNC:17350] |
| Ensembl ID | ENSG00000168438 |
| Bio databases IDs | |
| Aliases | cell division cycle 40 |
| Synonyms | 1200003H23Rik, cell division cycle 40, EHB3, EH-binding protein 3, hPRP17, LOC100504956, PCH15, PRP17, PRPF17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- NPF motif
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pontocerebellar hypoplasia type 15
- congenital pontocerebellar hypoplasia
- Hutchinson-Gilford progeria syndrome
- productive infection by HIV-1
role in cell
- cell viability
- Clathrin mediated endocytosis by
- splicing by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- catalytic step 2 spliceosome
- nuclear speck
- U2-type catalytic step 2 spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding