SLC25A6 Gene Summary [Human]

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Details

Type
Protein Coding
Official Symbol
SLC25A6
Official Name
solute carrier family 25 member 6 [Source:HGNC Symbol;Acc:HGNC:10992]
Ensembl ID
ENSG00000169100
Bio databases IDs NCBI: 293 Ensembl: ENSG00000169100
Aliases solute carrier family 25 member 6
Synonyms AAC3, ADP/ATP TRANSLOCASE, ADT3, ANC3, ANT, ANT 2, ANT 3, ANT3Y, solute carrier family 25 member 6
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC25A6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mitochondrial carrier protein
  • protein binding
  • transporter

Pathways

Biological processes and signaling networks where the SLC25A6 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • breast cancer
  • prostate cancer
  • Klinefelter syndrome
  • knee osteoarthritis
  • COVID-19
  • postmenopausal osteoporosis
  • Parkinson disease
  • progressive familial intrahepatic cholestasis type 1
  • pain
  • Turner syndrome
regulated by
regulates
role in cell
  • apoptosis
  • proliferation
  • cell death
  • transmembrane potential
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cellular membrane
  • inner membrane
  • Mitochondria
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC25A6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • apoptotic process

Cellular Component

Where in the cell the gene product is active
  • mitochondrial inner membrane presequence translocase complex
  • nucleus
  • mitochondrion
  • membrane
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • ATP:ADP antiporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.