ARAF Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in negative regulation of apoptotic process; regulation of TOR signaling; and regulation of cellular protein metabolic process. Predicted to be active in cytosol and mitochondrion. Biomarker of high grade glioma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARAF |
| Official Name | A-Raf proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:646] |
| Ensembl ID | ENSG00000078061 |
| Bio databases IDs | |
| Aliases | A-Raf proto-oncogene, serine/threonine kinase |
| Synonyms | 1200013E08Rik, ARAF1, A-Raf proto-oncogene, serine/threonine kinase, PKS, PKS2, RAFA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARAF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- Protein tyrosine and serine/threonine kinase
- CR1 domain
- CR2 domain
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- dimer interface domain
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Raf-like Ras-binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Ubl1_cv_Nsp3_N-like
- alcohol group acceptor phosphotransferase
- Ras-binding domain
- tail domain
- Tyrosine kinase, catalytic domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the ARAF gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Adrenomedullin signaling pathway
- Cancer Drug Resistance By Drug Efflux
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Ephrin A Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-8 Signaling
- Melatonin Signaling
- NF-κB Signaling
- Polyamine Regulation in Colon Cancer
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- UVC-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast cancer
- neoplasia
- metastasis
- adenoma formation
- metastatic melanoma
- athetotic walking
- thyroid oncocytic carcinoma
- papillary thyroid carcinoma
- cutaneous melanoma
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- binding in
- apoptosis
- replication in
- growth
- activation in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- cytoskeleton
- perinuclear region
- vesicles
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARAF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- protein modification process
- negative regulation of apoptotic process
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of TOR signaling cascade
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity