ZNF354A Gene Summary [Human]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF354A |
| Official Name | zinc finger protein 354A [Source:HGNC Symbol;Acc:HGNC:11628] |
| Ensembl ID | ENSG00000169131 |
| Bio databases IDs | |
| Aliases | zinc finger protein 354A |
| Synonyms | EZNF, HEL104, HKL1, KID-1, TCF17, ZFP354A, Zinc finger protein 354A, Zpf354a |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF354A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- krueppel associated box
- transcription regulator
- Zinc-finger double domain
- zinc finger domain
- KRAB (Kruppel-associated box) domain -A box
- transcription factor activity
Pathways
Biological processes and signaling networks where the ZNF354A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF354A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity