MAGEB2 Gene Summary [Human]
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAGEB2 |
| Official Name | MAGE family member B2 [Source:HGNC Symbol;Acc:HGNC:6809] |
| Ensembl ID | ENSG00000099399 |
| Bio databases IDs | |
| Aliases | MAGE family member B2, DSS/AHC critical interval MAGE superfamily 6, melanoma-associated antigen B2, cancer/testis antigen family 3, member 2 |
| Synonyms | CT3.2, DAM6, MAGE family member B2, MAGE-XP-2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGEB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanoma associated antigen family N terminal
- MAGE homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neuroblastoma formation
- neuroblastoma
role in cell
- expression in
- proliferation
- apoptosis
- formation
- cell cycle progression
- translation in
- formation in
- Wnt signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGEB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding