GP2 Gene Summary [Human]
This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | GP2 |
| Official Name | glycoprotein 2 [Source:HGNC Symbol;Acc:HGNC:4441] |
| Ensembl ID | ENSG00000169347 |
| Bio databases IDs | |
| Aliases | glycoprotein 2 |
| Synonyms | 2310037I18Rik, glycoprotein 2, glycoprotein 2 zymogen granule membrane, gp80, ZAP75 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- antigen binding
- protein binding
- glycosylphosphatidylinositol anchor sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Plasma Membrane
- endosomes
- plasma membrane extracellular face
- apical membrane
- zymogen granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen transcytosis by M cells in mucosal-associated lymphoid tissue
- innate immune response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- endosome
- membrane raft
- external side of plasma membrane
- extracellular region
- apical plasma membrane
- plasma membrane
- zymogen granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- antigen binding