GLP1R Gene Summary [Human]
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | GLP1R |
| Official Name | glucagon like peptide 1 receptor [Source:HGNC Symbol;Acc:HGNC:4324] |
| Ensembl ID | ENSG00000112164 |
| Bio databases IDs | |
| Aliases | glucagon like peptide 1 receptor |
| Synonyms | Glip, GLP-1, GLP1Rc, GLP-1 receptor, Glpr1, Glucagon-Like Peptide 1 Receptor, RATGL1RCP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLP1R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- G-protein coupled peptide receptor
- 7 transmembrane receptor (Secretin family)
- signaling receptor activity
- intracellular domain
- protein binding
- peptide receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- transmembrane receptor
- phosphorylation site
Pathways
Biological processes and signaling networks where the GLP1R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- overweight disorder
- weight loss
- morbid obesity
- non-insulin-dependent diabetes mellitus
- polycystic ovary syndrome
- colorectal cancer
- acute coronary syndrome
- disorder of coronary artery
- acute ischemic stroke
role in cell
- phosphorylation in
- formation in
- apoptosis
- quantity
- expression in
- production in
- binding in
- proliferation
- activation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveosome
- cell surface
- cellular membrane
- nerve ending
- membrane rafts
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLP1R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart contraction
- negative regulation of blood pressure
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- hormone secretion
- positive regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- learning or memory
- cellular response to glucagon stimulus
- posttranslational protein targeting to membrane, translocation
- activation of adenylate cyclase activity
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucagon-like peptide 1 receptor activity
- protein binding
- transmembrane signaling receptor activity
- glucagon receptor activity
- peptide hormone binding