HMGN5 Gene Summary [Human]
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | HMGN5 |
| Official Name | high mobility group nucleosome binding domain 5 [Source:HGNC Symbol;Acc:HGNC:8013] |
| Ensembl ID | ENSG00000198157 |
| Bio databases IDs | |
| Aliases | high mobility group nucleosome binding domain 5 |
| Synonyms | GARP45, high-mobility group nucleosome binding domain 5, NBP-45, NSBP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGN5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- chromatin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- pulmonary emphysema
role in cell
- apoptosis
- binding in
- binding
- proliferation
- number
- frequency
- decompaction
- decompaction in
- organization
- abnormal number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGN5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- nucleosomal DNA binding
- chromatin binding