VPREB1 Gene Summary [Human]
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | VPREB1 |
| Official Name | V-set pre-B cell surrogate light chain 1 [Source:HGNC Symbol;Acc:HGNC:12709] |
| Ensembl ID | ENSG00000169575 |
| Bio databases IDs | |
| Aliases | V-set pre-B cell surrogate light chain 1 |
| Synonyms | CD179a, IGI, IGVPB, LOC100911573, LOC683117, VPREB, Vpreb1a, V-set pre-B cell surrogate light chain 1, V-set pre-B cell surrogate light chain 1A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPREB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- tail domain
- protein binding
- unique protein domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Ca2+
- Immunoglobulin
- IgG
- Prebcr
role in cell
- quantity
- number
- differentiation
- proliferation
- abnormal morphology
- generation
- hematopoiesis
- size
- development
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPREB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- immunoglobulin production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- extracellular region