Vpreb1 Gene Summary [Mouse]
Enables signaling receptor activity. Acts upstream of or within several processes, including B cell homeostasis; B cell proliferation; and regulation of cell size. Located in external side of plasma membrane. Is expressed in bone marrow; liver; and spleen. Orthologous to human VPREB1 (V-set pre-B cell surrogate light chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vpreb1 |
| Official Name | pre-B lymphocyte gene 1 [Source:MGI Symbol;Acc:MGI:98936] |
| Ensembl ID | ENSMUSG00000059305 |
| Bio databases IDs | |
| Aliases | pre-B lymphocyte gene 1 |
| Synonyms | CD179a, IGI, IGVPB, LOC100911573, LOC683117, VPREB, Vpreb1a, V-set pre-B cell surrogate light chain 1, V-set pre-B cell surrogate light chain 1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vpreb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- tail domain
- protein binding
- unique protein domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Ca2+
- Immunoglobulin
- IgG
- Prebcr
role in cell
- quantity
- number
- differentiation
- proliferation
- abnormal morphology
- generation
- hematopoiesis
- size
- development
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vpreb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- immunoglobulin production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- extracellular region