CLIC3 Gene Summary [Human]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLIC3 |
| Official Name | chloride intracellular channel 3 [Source:HGNC Symbol;Acc:HGNC:2064] |
| Ensembl ID | ENSG00000169583 |
| Bio databases IDs | |
| Aliases | chloride intracellular channel 3 |
| Synonyms | 2300003G24Rik, chloride intracellular channel 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- chloride channel
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein-disulfide reductase (glutathione)
- protein binding
- intracellular chloride channel protein
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- bladder cancer
- systemic lupus erythematosus
- Rett syndrome
regulates
- CDKN1A
- chloride
- CD8 (family)
role in cell
- killing
- expression in
- proliferation
- Clathrin mediated endocytosis by
- killing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear bodies
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- nucleus
- extracellular vesicular exosome
- nuclear body
- cytoplasm
- membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein-disulfide reductase (glutathione) activity
- chloride channel activity