PAN3 Gene Summary [Human]
Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | PAN3 |
| Official Name | poly(A) specific ribonuclease subunit PAN3 [Source:HGNC Symbol;Acc:HGNC:29991] |
| Ensembl ID | ENSG00000152520 |
| Bio databases IDs | |
| Aliases | poly(A) specific ribonuclease subunit PAN3 |
| Synonyms | 2700050F09RIK, A430027N15RIK, AU014670, PAN3 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pan3 Pseudokinase domain
- poly(A)-specific ribonuclease
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic mRNA processing body
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoplasmic mRNA processing body assembly
- mRNA processing
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- PAN complex
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- ATP binding
- protein binding
- metal ion binding
- poly(A) RNA binding
- protein kinase activity