CENPX Gene Summary [Human]
Enables DNA binding activity. Contributes to double-stranded DNA binding activity. Involved in replication fork processing and resolution of meiotic recombination intermediates. Part of FANCM-MHF complex and Fanconi anaemia nuclear complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CENPX |
| Official Name | centromere protein X [Source:HGNC Symbol;Acc:HGNC:11422] |
| Ensembl ID | ENSG00000169689 |
| Bio databases IDs | |
| Aliases | centromere protein X |
| Synonyms | centromere protein X, D9, D9 splice variant A, FAAP10, MHF2, STRA13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription repression domain
- double-stranded DNA binding
- alpha helix
- CENP-S associating Centromere protein X
- protein binding
- helix-loop-helix domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- colon carcinoma
- colon epithelial cancer
role in cell
- quantity
- proliferation
- degeneration
- differentiation
- processing
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of protein ubiquitination
- kinetochore assembly
- resolution of meiotic recombination intermediates
- chromosome segregation
- replication fork processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- Fanconi anaemia nuclear complex
- cytosol
- FANCM-MHF complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- double-stranded DNA binding