NKX3-1 Gene Summary [Human]
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | NKX3-1 |
| Official Name | NK3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7838] |
| Ensembl ID | ENSG00000167034 |
| Bio databases IDs | |
| Aliases | NK3 homeobox 1 |
| Synonyms | bagpipe, BAPX2, Bax, NK3 homeobox 1, NKX3, NKX3.1, NKX3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKX3-1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- transcription factor binding
- histone deacetylase binding
- protein domain specific binding
- estrogen receptor binding
- caspase activator
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the NKX3-1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cancer
- epithelial cancer
- tumorigenesis
- hyperplasia
- hypoplasia
- prostatic carcinoma
- prostate cancer
- colorectal cancer
role in cell
- proliferation
- phosphorylation in
- accumulation in
- expression in
- activation in
- growth
- formation
- formation in
- degradation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKX3-1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- branching involved in prostate gland morphogenesis
- male gonad development
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- epithelial cell proliferation involved in prostate gland development
- branching morphogenesis of a tube
- salivary gland development
- positive regulation of transcription from RNA polymerase II promoter
- epithelial cell proliferation involved in salivary gland morphogenesis
- negative regulation of insulin-like growth factor receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- protein kinase B signaling cascade
- positive regulation of cell division
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- apoptotic process
- positive regulation of androgen secretion
- cellular response to tumor necrosis factor
- response to testosterone stimulus
- cellular response to hypoxia
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- androgen receptor signaling pathway
- positive regulation of intrinsic apoptotic signaling pathway
- negative regulation of epithelial cell proliferation involved in prostate gland development
- regulation of protein localization
- regulation of transcription, DNA-dependent
- pharyngeal system development
- response to DNA damage stimulus
- positive regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- dorsal aorta development
- cellular response to steroid hormone stimulus
- negative regulation of gene expression
- metanephros development
- somitogenesis
- positive regulation of gene expression
- negative regulation of epithelial cell proliferation
- positive regulation of protein phosphorylation
- cell differentiation
- cellular response to interleukin-1
- cellular response to xenobiotic stimulus
- positive regulation of protein kinase B signaling cascade
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- estrogen receptor binding
- MADS box domain binding
- cysteine-type endopeptidase activator activity involved in apoptotic process
- sequence-specific DNA binding RNA polymerase II transcription factor activity