P2RY1 Gene Summary [Human]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | P2RY1 |
| Official Name | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] |
| Ensembl ID | ENSG00000169860 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y1, suppressing androgen receptor in renal cell carcinoma |
| Synonyms | P2y, P2Y1, P2y1r, P2Y1 receptor, purinergic receptor P2Y1, purinergic receptor P2Y, G-protein coupled 1, SARCC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- ATP-activated nucleotide receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- receptor regulator
- purinergic G-protein coupled nucleotide receptor
- ADP binding
- G-protein-coupled receptor binding
- ATP binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- cytosolic tail domain
- platelet ADP receptor
- PDZ binding motif
- protein heterodimerization
Pathways
Biological processes and signaling networks where the P2RY1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- cardiovascular disorder
- non-Q wave myocardial infarction
- overweight disorder
- hypertension
- atrial fibrillation
- acute myocardial infarction
- diabetes mellitus
- acute ST-elevation myocardial infarction
- peripheral arterial disease
role in cell
- phosphorylation in
- migration
- proliferation
- activation in
- expression in
- binding in
- production in
- inhibition in
- activation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- intracellular compartment
- cilia
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- vesicles
- demarcation membrane systems
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- alpha granules
- axon initial segments
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- regulation of cell shape
- response to growth factor stimulus
- signal transduction involved in regulation of gene expression
- positive regulation of penile erection
- relaxation of muscle
- positive regulation of transcription from RNA polymerase II promoter
- glial cell migration
- eating behavior
- response to mechanical stimulus
- ion transport
- positive regulation of ion transport
- establishment of localization in cell
- cellular response to ATP
- platelet activation
- positive regulation of inositol trisphosphate biosynthetic process
- cellular response to purine-containing compound
- G-protein coupled receptor signaling pathway
- positive regulation of hormone secretion
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- adenosine receptor signaling pathway
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- regulation of synaptic vesicle exocytosis
- negative regulation of norepinephrine secretion
- protein localization in plasma membrane
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- postsynaptic membrane
- cell body
- cilium
- presynaptic active zone membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP-activated nucleotide receptor activity
- ATP binding
- scaffold protein binding
- ADP receptor activity
- protein binding
- protein heterodimerization activity
- signaling receptor activity
- G-protein coupled purinergic nucleotide receptor activity
- ADP binding
- A1 adenosine receptor binding