VKORC1L1 Gene Summary [Human]
This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | VKORC1L1 |
| Official Name | vitamin K epoxide reductase complex subunit 1 like 1 [Source:HGNC Symbol;Acc:HGNC:21492] |
| Ensembl ID | ENSG00000196715 |
| Bio databases IDs | |
| Aliases | vitamin K epoxide reductase complex subunit 1 like 1 |
| Synonyms | 2310024K08RIK, LOC103693015, vitamin K epoxide reductase complex subunit 1 like 1, vitamin K epoxide reductase complex, subunit 1-like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VKORC1L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin-K-epoxide reductase (warfarin-sensitive)
- enzyme
- protein binding
- Vitamin K epoxide reductase (VKOR) family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
regulates
- vitamin K
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VKORC1L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitamin K metabolic process
- peptidyl-glutamic acid carboxylation
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- quinone binding
- vitamin-K-epoxide reductase (warfarin-sensitive) activity