OTUD7A Gene Summary [Human]
The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | OTUD7A |
| Official Name | OTU deubiquitinase 7A [Source:HGNC Symbol;Acc:HGNC:20718] |
| Ensembl ID | ENSG00000169918 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase 7A |
| Synonyms | C15orf16, C16ORF15, CEZANNE2, NEDHS, OTUD7, OTU deubiquitinase 7A, OTU domain containing 7A, RGD1563721 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OTUD7A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- UBA-like domain
- peptidase
- ubiquitin-specific protease
- A20-like zinc finger
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OTUD7A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked deubiquitination
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- proteolysis
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- DNA binding
- zinc ion binding
- K63-linked polyubiquitin binding