CDC42BPA Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
Details
| Type | Protein Coding |
| Official Symbol | CDC42BPA |
| Official Name | CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737] |
| Ensembl ID | ENSG00000143776 |
| Bio databases IDs | |
| Aliases | CDC42 binding protein kinase alpha, myotonic dystrophy kinase-related Cdc42-binding kinase |
| Synonyms | A930014J19RIK, CDC42 binding protein kinase alpha, CDC42 binding protein kinase α, DMPK-like, KIAA0451, MRCK, MRCKA, MRCK-alpha, MRCK-α, PK428 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC42BPA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- Autophagy protein 16 (ATG16)
- kinase inhibitory region domain
- Synaptonemal complex protein 1 (SCP-1)
- ATP binding
- KELK-motif containing domain of MRCK Ser/Thr protein kinase
- coiled-coil domain
- Protein kinase domain
- identical protein binding
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- Tyrosine kinase, catalytic domain
- cysteine rich domain
- Protein kinase (unclassified specificity)
- Tropomyosin like
- Protein kinase C terminal domain
- catalytic domain
- Hyaluronan mediated motility receptor N-terminal
- Protein tyrosine and serine/threonine kinase
- CNH domain
- DMPK coiled coil domain like
- protein binding
- Pleckstrin homology-like domain
- magnesium ion binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Domain of unknown function (DUF4686)
- Mechanosensitive ion channel porin domain
- CRIB
- Protein Kinases, catalytic domain
- Trichohyalin-plectin-homology domain
- Cdc42 binding domain
- Growth-arrest specific micro-tubule binding
Pathways
Biological processes and signaling networks where the CDC42BPA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cataract
- squamous-cell carcinoma
- squamous cell cancer
- pervasive developmental disorder
- open-angle glaucoma
role in cell
- formation
- survival
- replication in
- invasion by
- migration
- organization
- outgrowth
- retraction in
- retraction
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cell periphery
- peripheral lamellae
- actin cytoskeleton
- intercellular junctions
- cytosol
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC42BPA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- protein phosphorylation
- cell migration
- actin cytoskeleton organization
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cell-cell junction
- cytoskeleton
- cytoplasm
- cell leading edge
- cytosol
- actomyosin
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity