TAS1R3 Gene Summary [Human]
The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | TAS1R3 |
| Official Name | taste 1 receptor member 3 [Source:HGNC Symbol;Acc:HGNC:15661] |
| Ensembl ID | ENSG00000169962 |
| Bio databases IDs | |
| Aliases | taste 1 receptor member 3 |
| Synonyms | Sac, T1R3, taste 1 receptor member 3, taste receptor, type 1, member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAS1R3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Receptor family ligand binding region
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the TAS1R3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
regulated by
- cisplatin
- SE-3
- mogroside
- sucrose
- neohesperidin dihydrochalcone
- alitame
- lactisole
- glycyrrhizic acid
- stevioside
- SE-2
role in cell
- expression in
- phosphorylation in
- activation in
- proliferation
- accumulation in
- activity
- motility
- size
- autophagy in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAS1R3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of umami taste
- G-protein coupled receptor signaling pathway
- sensory perception of sweet taste
- detection of chemical stimulus involved in sensory perception of sweet taste
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sweet taste receptor activity
- G-protein coupled receptor activity
- taste receptor activity