Tas1r3 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and taste receptor activity. Predicted to contribute to sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in Golgi apparatus. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Is expressed in circumvallate papillae and tongue anterior part. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tas1r3 |
| Official Name | taste receptor, type 1, member 3 [Source:MGI Symbol;Acc:MGI:1933547] |
| Ensembl ID | ENSMUSG00000029072 |
| Bio databases IDs | |
| Aliases | taste receptor, type 1, member 3 |
| Synonyms | Sac, T1R3, taste 1 receptor member 3, taste receptor, type 1, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tas1r3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Receptor family ligand binding region
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tas1r3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
regulated by
- cisplatin
- SE-3
- mogroside
- sucrose
- neohesperidin dihydrochalcone
- alitame
- lactisole
- glycyrrhizic acid
- stevioside
- SE-2
role in cell
- expression in
- phosphorylation in
- activation in
- proliferation
- accumulation in
- activity
- motility
- size
- autophagy in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tas1r3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of umami taste
- G-protein coupled receptor signaling pathway
- sensory perception of sweet taste
- detection of chemical stimulus involved in sensory perception of sweet taste
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sweet taste receptor activity
- G-protein coupled receptor activity
- taste receptor activity